Table of contents

• “Diet IV Therapy” as a Weight Management Approach
• Prescription "Diet Pills" for Weight Management
• Best Clinics in Korea for Medication Weight Gain
• Seeking Weight Management Solutions in South Korea: A Medical Tourist Perspective
• Patient Experiences and Clinical Perspectives
• Conclusion
• References

This guide explores solutions for individuals experiencing weight gain as a side effect of prescription medications. We examine the reasons behind medication-induced weight gain, introduce key terms such as "iatrogenic obesity" and "drug weight gain," and compare two popular weight management options: "Diet IV therapy" and prescription "Diet Pills." The article explains each procedure, details the patient process in South Korea for medical tourists, summarizes related costs, and discusses patient and clinical experiences internationally. Evidence-based practices and the importance of medical consultation are emphasized throughout. Prescription weight loss medications show proven results—especially in addressing medication-induced weight gain—whereas "Diet IV therapy" lacks strong scientific support and presents potential risks. South Korea offers competitive pricing on certain treatments, but patients should thoroughly understand all related expenses and the medical process.

Medication-induced weight gain is a widespread yet often overlooked issue, impacting many who take prescription drugs for various health conditions. This section clarifies what it is, how it happens, and which medications are likely to cause it.

What is Medication-Induced Weight Gain?

Medication-induced weight gain is the unintended increase in body weight that some people experience after starting certain prescription medications. This side effect is significant—not just for personal health, but from a public health perspective—and can mean gaining several pounds or even over 10% of one’s body weight. Patients often use the term "drug weight gain," while medical literature may refer to it as "iatrogenic obesity." It’s estimated that 10–15% of weight gain cases result from medication use, highlighting how common this issue is. Many patients may not connect sudden weight changes with their prescriptions, which can lead to misdiagnosis or emotional distress.

How Medications Cause Weight Gain: Mechanisms

Several mechanisms explain how medications can increase weight:

• Appetite stimulation: Some drugs make people feel hungrier, leading to higher food intake.
• Fat storage stimulation: Others affect the way the body manages glucose, resulting in greater fat accumulation, especially in the midsection.
• Metabolic slowdown: Medications can reduce metabolic rate, so fewer calories are burned at rest.
• Fluid retention: Many drugs cause the body to hold onto more water, increasing weight.
• Exercise impairment: Certain medications, such as opioids, can lower exercise tolerance, making it harder to burn calories effectively.

The combined impact of multiple drugs (polypharmacy) can complicate tracking causes and finding solutions, making careful management and communication between patients and doctors essential.

Common Medications Associated with Weight Gain

Numerous medication classes are linked to weight gain:

• Antidepressants, Anti-anxiety, and Mood Stabilizers: SSRIs like Paxil, Zoloft, Celexa, Prozac, Sertraline, and Paroxetine, as well as older antidepressants, MAOIs, benzodiazepines, and lithium.
• Antipsychotics: Olanzapine, Clozapine, Risperidone, Quetiapine, Aripiprazole, Haloperidol, with Olanzapine and Clozapine carrying the greatest risk.
• Diabetes Medications: Insulin, Sulfonylureas, Thiazolidinediones, Nateglinide, and Repaglinide.
• Steroid Hormones: Corticosteroids, Medroxyprogesterone, progestins, and some contraceptives; certain chemotherapy drugs like Tamoxifen and Arimidex.
• Anticonvulsants, Anti-migraine, and Neuropathic Pain Drugs: Gabapentin, Pregabalin, Valproic acid, Carbamazepine, Divalproex.
• Anti-hypertensive Medications: Beta-blockers, Alpha-blockers, and Calcium channel blockers.
• Antihistamines: Diphenhydramine, Fexofenadine, Cetirizine.
• Other Medications: Hypnotics (Remeron, Zolpidem), and certain anti-retrovirals.

Because so many medications from various specialties contribute to weight gain, a team approach and open communication become vital for effective management.

“Diet IV Therapy” as a Weight Management Approach

“Diet IV therapy,” the intravenous infusion of vitamins, minerals, and other nutrients, is increasingly marketed as a quick fix for weight loss. Here, we look at how it works, its touted benefits, the scientific evidence, and real risks.

Description and Components

Diet IV therapy involves infusing fluids, vitamins, minerals, or medications directly into the bloodstream through a vein, often in the arm or hand, enabling immediate absorption. This is useful for individuals with malabsorption or those recovering from illness or surgery. Typical nutrients in these drips include B Complex vitamins, Vitamin C, Zinc, Magnesium, and occasionally compounds like "Lipo C" (Methionine, Inositol, Choline), L-Carnitine, and Glutathione. Certain IV therapies may also include medications such as Peptide YY agonists or bimagrumab.

Claimed Benefits and Scientific Evidence

Proponents suggest that Diet IV therapy quickens metabolism, boosts energy, burns fat, and improves sleep by ensuring nutrients are absorbed efficiently. Clinics often market it as an effective wellness solution, particularly for people feeling rundown from dieting. However, the scientific evidence for its direct effect on weight loss is minimal. The FDA does not approve IV therapies for weight loss, and respected medical organizations do not recommend them for this purpose. Some studies have indicated minor subjective improvements in energy or mood, but any resulting weight changes are typically due to combined lifestyle modifications rather than the IV therapy itself.

Risks and Concerns

Though IV therapy can be safe when medically indicated and administered by trained professionals, its elective use poses several risks:

• Nutrient overdose: Bypassing digestive safeguards can lead to excessive doses, risking toxicity.
• Air embolism: Air entering the bloodstream can have serious consequences.
• Allergic reactions: Components in the drip may trigger adverse responses.
• Blood clots, infection, and tissue injury: Inserting an IV can increase these risks, especially if not conducted in sterile conditions.
• Fluid overload and electrolyte imbalances: Dangerous for those with kidney or heart conditions.
• Metabolic abnormalities and liver dysfunction: Long-term use increases the risks further.

Most experts recommend dietary improvements or oral supplements as safer and more cost-effective alternatives for the general public.

Prescription "Diet Pills" for Weight Management

Prescription "diet pills" are a well-established medical solution for weight gain—especially when lifestyle changes alone aren’t enough. Let’s break down how these drugs work, what’s available, how effective they are, and what side effects to consider.

Description and Mechanisms of Action

Prescription weight loss medications are recommended for individuals with a BMI of 30+ (or 27+ with certain health issues). When paired with a healthy diet and exercise, these medications enhance weight loss via three main pathways:

• Appetite suppression: Medications such as bupropion-naltrexone (Contrave) and phentermine-topiramate (Qsymia) reduce hunger by influencing brain chemistry.
• Fat absorption inhibition: Orlistat (Xenical, Alli) blocks fat absorption in the gut, decreasing caloric intake.
• Hormonal regulation (GLP-1 receptor agonists): Medications like Semaglutide (Wegovy, Ozempic) and Tirzepatide (Zepbound, Mounjaro) mimic hormones that slow stomach emptying and curb appetite, also improving blood sugar regulation.

Common FDA-Approved Weight Loss Medications

Prominent prescription drugs include:

• Orlistat (Xenical, Alli)
• Bupropion-naltrexone (Contrave)
• Liraglutide (Saxenda)
• Phentermine-topiramate (Qsymia)
• Semaglutide (Wegovy)
• Tirzepatide (Zepbound)
• Setmelanotide (Imcivree, for certain genetic obesity conditions)

Efficacy and Side Effects

Prescription weight loss medications, especially newer GLP-1 agonists, can produce 5–16% (or more) weight loss when combined with lifestyle change. For example, Wegovy users often lose at least 5% of initial body weight, and Zepbound may result in up to 18% reduction. However, stopping medication often leads to weight regain, underscoring the importance of ongoing healthy habits.

Common side effects include nausea, diarrhea, constipation, headaches, and, with Orlistat, fatty stools. GLP-1 agonists sometimes cause “sulphur burps,” dry mouth, or site irritation (for injectables). Cost and insurance coverage should also be considered, as these medications can be expensive.

Best Clinics in Korea for Medication Weight Gain

Listed below are the best clinics in Korea for medication weight gain:

365mc Hospital

365mc Hospital stands as Korea’s leading clinic dedicated exclusively to obesity treatment, body contouring, and fat reduction. With more than 20 years in the field and a network of 18 clinics operated by 22 main doctors, 365mc is highly regarded for its strict hospital-level safety standards, innovative procedures, and exceptional patient care. As the first and only hospital in Korea solely focused on body fat and contouring, 365mc provides liposuction services using advanced technology, including the AI-powered M.A.I.L. System developed in partnership with Microsoft, ensuring unparalleled precision and outcomes. This commitment to surgical excellence and safety is recognized by the Korean Health Ministry Seal and is reflected in the clinic's record of over 5 million procedures and more than 3,000 successful surgical liposuctions.

At 365mc, each patient receives personalized, intensive care, starting with private 1:1 attention on the day of the procedure and continuing through a structured 7-week recovery program. This comprehensive program integrates hyperbaric oxygen therapy, customized dietary consultations, and continual monitoring to encourage a swift and comfortable recovery while optimizing body sculpting results. Beyond surgical interventions, 365mc is known for its groundbreaking Local Anesthetic Minimal-Invasive Liposuction (LAMS) technique, bespoke Hourglass Hip program, and expert-led nutrition counseling. Through a foundation of cutting-edge technology, individualized care, and a holistic approach to patient well-being, 365mc redefines the standards for obesity treatment and post-medication weight management in Korea.

You can check out their website here: 365mc Hospital Website

365mc Hospital - Sinsa

365mc Hospital - Sinsa stands out as the premier clinic for addressing medication-induced weight gain in Korea due to its outstanding expertise and client-centered approach in obesity management. Renowned for its specialization in state-of-the-art procedures, 365mc Hospital offers a comprehensive range of liposuction options—including those targeting the abdomen, arms, thighs, love handles, and facial areas—enabling personalized and effective fat reduction for each client’s unique needs. Their highly trained professionals utilize the latest technology and advanced techniques to ensure safe, precise, and aesthetically pleasing outcomes. The introduction of LAMS (Liposuction Assisted Morphological Surgery), a minimally invasive procedure developed to deliver targeted contouring with minimal downtime, further exemplifies their commitment to innovative treatment and client satisfaction. As a leader in obesity treatment in South Korea, 365mc’s Sinsa branch provides a trusted destination for individuals seeking optimal results and renewed confidence after experiencing weight gain associated with medication.

You can check out their website here: 365mc Hospital - Sinsa Website

Three Wishes Clinic - Myeongdong

Three Wishes Clinic - Myeongdong stands at the forefront of advanced aesthetic medicine in Seoul, offering a comprehensive range of modern treatments with a focus on individualized care and patient satisfaction. Conveniently located just steps from Myeongdong Station exit 9, the clinic has established a strong reputation for both its exceptional results and unwavering commitment to safety and professionalism. Highly praised by past patients and recognized for innovative techniques, Three Wishes Clinic is a leader in aesthetic solutions, making it the top choice for those seeking to address medication-induced weight gain through targeted procedures.

Highlights of Three Wishes Clinic’s strengths in managing Medication Weight Gain:

• Prime central location in Myeongdong for easy access and discreet care.
• A multidisciplinary team of medical professionals with extensive expertise in facial and body aesthetics.
• Cutting-edge treatments such as fat dissolving injections and body contouring options, ideal for patients experiencing weight gain due to medication.
• Full suite of minimally invasive treatments—Botox, fillers, thread lifting—designed to restore natural contours and confidence.
• A patient-centered approach focused on safety, satisfaction, and tailored treatment plans for optimal results.
• State-of-the-art technology, ensuring advanced and effective solutions for safe body reshaping.
• Consistently high satisfaction rates and excellent patient reviews, affirming trust and reliability.
• Comprehensive aftercare and follow-up to ensure sustained results and overall well-being.

Three Wishes Clinic- Myeongdong is the premier destination for anyone seeking expert, safe, and customized care to address medication weight gain and enhance overall self-image.

You can check out their website here: Three Wishes Clinic - Myeongdong Website

Seeking Weight Management Solutions in South Korea: A Medical Tourist Perspective

South Korea is gaining global attention for affordable, high-quality medical care. Here’s what you need to know if you’re considering weight management therapies as a medical tourist.

Overview of Medical Tourism in South Korea

With a medical tourism industry valued at $2.0 billion in 2024 and sophisticated packages that include everything from consultations to accommodation, South Korea is a preferred destination for patients seeking affordable, advanced, and convenient care. The government enforces rigorous safety standards and offers integrated service packages for international visitors.

Process for Obtaining “Diet IV Therapy”

Medical tourists typically begin with a detailed consultation, during which a healthcare professional creates a custom nutrient IV plan. Major clinics will monitor vital signs during and after administration, and further sessions may be recommended as needed. However, this procedure is not FDA-approved for weight loss, and patients—especially those with fluid retention or heart/kidney conditions—should exercise caution and consult thoroughly with clinicians beforehand.

Process for Obtaining Prescription “Diet Pills”

Patients interested in prescription diet pills in South Korea visit a clinic for evaluation and personalized planning. Leading providers will investigate your medical history and weight-related goals before prescribing drugs like Wegovy, which must be dispensed by a licensed pharmacist. You may need to put down a deposit. Policies for foreign patients vary, so direct consultation with Korean clinics is recommended for precise requirements.

Associated Costs and International Comparison

Diet IV Therapy in South Korea:

• $40–$225 USD per session, sometimes bundled for multiple treatments.

International IV Therapy Costs:

• USA: $150–$400 per session
• Turkey: $75–$250
• Canada: $140–$315

Prescription Diet Pills in South Korea:

• Wegovy: $294–$735 USD per month, with similar drugs in the $294–$735 range.
• US prices are often 2–5x higher than those in Korea.

Overall Medical Tourism Costs:

• Patients must account for medical fees, travel, lodging, companion expenses, and out-of-pocket post-care. For example, bariatric surgery might cost $6,000–$9,000 in Korea versus $18,000–$25,000 in the US.

Patient Experiences and Clinical Perspectives

“Diet IV Therapy” for Medication-Induced Weight Gain

Patients who use Diet IV therapy mostly report feeling more energetic, clear-headed, or rejuvenated—particularly during recovery or after intense workouts. However, these experiences are largely anecdotal, with weight loss more likely tied to improved lifestyle efforts alongside the treatment than to the IV therapy alone.

Prescription “Diet Pills” for Medication-Induced Weight Gain

Patients on prescription medications, especially GLP-1 receptor agonists, describe notable weight reduction, less hunger, and reduced “food noise.” Some, like Andrea (on semaglutide), found it transformative for both physical and mental health. Mounjaro users have reported steady weight loss with minimal side effects. Managing mild to moderate side effects is often possible with lifestyle adjustments. These medications typically require long-term commitment; stopping them often results in regain.

Clinical Perspectives on Addressing Medication-Induced Weight Gain

Clinicians take a comprehensive approach that includes:

• Reviewing current medications to spot weight-gaining agents
• Making informed substitutions when possible
• Integrating lifestyle counseling (diet, exercise)
• Adding evidence-based medications (e.g., GLP-1 agonists) when needed

Combined care from physicians, dietitians, and specialists is critical. For patients with psychiatric medication-induced weight gain or diabetes, GLP-1 agonists demonstrate both weight loss efficacy and stability in mental health conditions.

Conclusion

Medication-induced weight gain, or iatrogenic obesity, frequently results from prescription drugs, but a variety of solutions exist. Evidence supports newer prescription "Diet Pills"—particularly GLP-1 agonists—as safe, effective options, while "Diet IV therapy" lacks strong scientific backing for weight loss. South Korea presents a cost-effective destination with advanced care, yet patients must fully research financial and medical requirements. A holistic, collaborative care approach is essential for success, and patients should always consult their healthcare provider to choose the safest and most effective weight management options.

References

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